Relationship between Retinal Microvasculature, Cardiovascular Risk and Silent Brain Infarction in Hypertensive Patients
Open Access
- 24 May 2021
- journal article
- research article
- Published by MDPI AG in Diagnostics
- Vol. 11 (6), 937
- https://doi.org/10.3390/diagnostics11060937
Abstract
Objective: The aims of this study are to analyze the role of artery-vein ratio AVR assessment using VesselMap 2 software (Imedos Systems) and cardiovascular risk evaluation by means of REGICOR in the prediction of silent brain infarction (SBI) in middle-age hypertensive patients from the ISSYS study. Material and Methods: A cross-sectional study with 695 patients with hypertension aged 50 to 70 years who participated in the project Investigating Silent Strokes in HYpertensives: a Magnetic Resonance Imaging Study (ISSYS), was conducted in two Primary Care Centres of Barcelona. Participants agreed to a retinography and an MRI to detect silent brain infarction (SBI). The IMEDOS software was used for the semiautomatic caliber measurement of retinal arteries and veins, and the AVR was considered abnormal when <0.66. The REGICOR score was calculated for all patients. Results: Multivariate logistic regression analysis was used to evaluate the impact of AVR and REGICOR scores on SBI. The OR (odds ratio) for a high REGICOR score and an abnormal AVR were 3.16 and 4.45, respectively. When analysing the interaction of both factors, the OR of an abnormal AVR and moderate REGICOR score was 3.27, whereas with a high REGICOR score it reached 13.07. Conclusions: The measurement of AVR in patients with hypertension and with a high REGICOR score can contribute to the detection of silent brain infarction.This publication has 35 references indexed in Scilit:
- Investigating silent strokes in hypertensives: a magnetic resonance imaging study (ISSYS): rationale and protocol designBMC Neurology, 2013
- Hypertensive Retinopathy and Risk of StrokeHypertension, 2013
- Retinal Microvascular Abnormalities and Cognitive Function in Latino Adults in Los AngelesOphthalmic Epidemiology, 2012
- In Vivo Assessment of Retinal Vascular Wall DimensionsInvestigative Ophthalmology & Visual Science, 2010
- Cardiovascular Risk-Estimation Systems in Primary PreventionCirculation, 2010
- Retinal Microvascular Abnormalities and Risk of Lacunar StrokeStroke, 2010
- Prediction of Incident Stroke Events Based on Retinal Vessel Caliber: A Systematic Review and Individual-Participant Meta-AnalysisAmerican Journal of Epidemiology, 2009
- Retinal microvascular abnormalities and cognitive dysfunction: a systematic reviewBritish Journal of Ophthalmology, 2008
- Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan StudyBrain, 2005
- Incidence, Manifestations, and Predictors of Brain Infarcts Defined by Serial Cranial Magnetic Resonance Imaging in the ElderlyStroke, 2002