The dialog between neurons and microglia in Alzheimer's disease: The neurotransmitters view
Open Access
- 12 December 2020
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 158 (6), 1412-1424
- https://doi.org/10.1111/jnc.15262
Abstract
Microglia play a vital role in maintaining brain homeostasis. Their continuous sensing of surrounding micro‐environments is crucial for their activity. Cross talk between specific neurons and microglia might occur through specific neurotransmitter receptors on microglia. Impairment with this interaction might result in pathological activity of microglia against potential insults. The reason for this activity in many neurodegenerative diseases such as Alzheimer's disease (AD) is not known. However, several papers report of the effects of different neurotransmitter agonists on microglial cells function that relate to their activity in AD. This review aims to summarize those works and to raise potential fundamental questions for future research.Keywords
Funding Information
- Israel Science Foundation (1365/19)
- Ministry of Science and Technology
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