Proteomic Analysis of Two Weight Classes of Mule Duck "foie gras" at the End of an Overfeeding Period
Open Access
- 17 September 2020
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Physiology
Abstract
The weight of the liver is one of the important selection criteria in the quality of "foie gras". This factor is highly variable despite the fact that individuals are reared, overfed and slaughtered in the same way. In this study, we performed an analysis of the proteome profile of two weight classes of light (between 550 and 599 g) and heavy (more than 700 g) livers. For the analysis of the proteic extracts, a liquid chromatographic analysis coupled with mass spectrometry was carried out. In low-weight livers, aerobic energy metabolism, protein metabolism and lipid metabolism oriented toward export and beta-oxidation were overexpressed. On the contrary, high weight livers were characterized by anaerobic energy metabolism and a more active protein catabolism associated with cell apoptosis and reorganization of the cell structure.Keywords
Funding Information
- Association Nationale de la Recherche et de la Technologie
- Ministère de l'Enseignement Supérieur et de la Recherche
This publication has 63 references indexed in Scilit:
- OGDHL Is a Modifier of AKT-Dependent Signaling and NF-κB FunctionPLOS ONE, 2012
- MMP Mediated Degradation of Type VI Collagen Is Highly Associated with Liver Fibrosis – Identification and Validation of a Novel Biochemical Marker AssayPLOS ONE, 2011
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1Cell, 2011
- Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implicationsExpert Review of Gastroenterology & Hepatology, 2011
- Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid MetabolismMolecular and Cellular Biology, 2009
- Induction of tropomyosin during hepatic stellate cell activation and the progression of liver fibrosisHepatology International, 2008
- Detection of novel biomarkers of liver cirrhosis by proteomic analysisHepatology, 2008
- Structural basis of cargo membrane protein discrimination by the human COPII coat machineryThe EMBO Journal, 2008
- Alpha-Tocopherol Transfer Protein (α-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout MiceNutrition Research and Practice, 2007
- Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Nature, 1970