Two intertwined compartments coexisting in sporadic conventional colon adenomas
Open Access
- 30 January 2021
- journal article
- review article
- Published by Korean Association for the Study of Intestinal Diseases in Intestinal Research
- Vol. 19 (1), 12-20
- https://doi.org/10.5217/ir.2019.00133
Abstract
Sporadic conventional colon adenomas are microscopically built of 2 intertwined compartments: one on top, harboring the dysplastic tissue that defines their histo-biomolecular attributes, and the other below, composed of non-dysplastic crypts with corrupted shapes (CCS). The CCS of 306 colon adenomas revealed asymmetric, haphazardly-distributed proliferating cell-domains (PC). In contrast, the PC-domains in normal controls were symmetric, being limited to the lower thirds of the crypts. In 28% out of 501 sporadic conventional adenomas, foci of p53-upregulated dysplastic tissue were found. The CCS in 30% of 108 sporadic adenomas showed p53-upregulated single cells, suggesting mounting somatic mutations. No p53-upregulated cells were found in the crypts of controls. In polypoid adenomas, the mucosa of the stalk without dysplastic tissue on top disclosed CCS with asymmetrical PC-domains and single p53-upregulated cells. The latter observations suggested that CCS had developed prior to and not after the growth of the dysplastic tissue on top. CCS were also found below colon adenomas in carcinogen-treated rats. It is concluded that the 2 intertwined histo-biological compartments of sporadic conventional colon adenomas are probably interdependent components. These findings may open new directions aimed to uncover the link between the normal colonic mucosa and the histogenesis of, conventional adenomas.Keywords
This publication has 57 references indexed in Scilit:
- Epigenetics and Colorectal Cancer PathogenesisCancers, 2013
- An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer DevelopmentFrontiers in Oncology, 2013
- Nonpolypoid neoplastic lesions of the colorectal mucosaGastrointestinal Endoscopy, 2008
- Review Article: Aberrant Crypt Foci: A ReviewToxicologic Pathology, 1999
- Aberrant Crypt Foci in the Human ColonThe American Journal of Surgical Pathology, 1999
- The role of aberrant crypt foci induced by the two heterocyclic amines 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ) and 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP) in the development of colon cancer in miceCancer Letters, 1996
- Mixed Hyperplastic Adenomatous Polyps/Serrated AdenomasThe American Journal of Surgical Pathology, 1990
- Morphometrical and Cell Kinetic Studies of Normal Human Colorectal MucosaActa Pathologica Japonica, 1989
- Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: Preliminary findingsCancer Letters, 1987
- Small “flat adenoma” of the large bowel with special reference to its clinicopathologic featuresDiseases of the Colon & Rectum, 1985