Proper Assignation of Reactivation in a COVID-19 Recurrence Initially Interpreted as a Reinfection
Open Access
- 9 June 2021
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 224 (5), 788-792
- https://doi.org/10.1093/infdis/jiab302
Abstract
A 77-year-old man (case R) with previous diagnosis of a mild COVID-19 episode was hospitalized 35 days later. On day 23 postadmission, he developed a second COVID-19 episode, now severe, and finally died. Initially, case R’s COVID-19 recurrence was interpreted as a reinfection due to the exposure to a SARS-CoV-2 RT-PCR–positive roommate. However, whole-genome sequencing indicated that case R’s recurrence corresponded to a reactivation of the strain involved in his first episode. Case R’s reactivation had major consequences, leading to a more severe episode, and causing subsequent transmission to another 2 hospitalized patients, 1 of them with fatal outcome.Keywords
Funding Information
- Instituto de Salud Carlos III (COV20/00140)
- Consejo Superior de Investigaciones Científicas
- Miguel Servet (CP15/00075)
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