The Close Relationship between the Golgi Trafficking Machinery and Protein Glycosylation
Open Access
- 10 December 2020
- Vol. 9 (12), 2652
- https://doi.org/10.3390/cells9122652
Abstract
Glycosylation is the most common post-translational modification of proteins; it mediates their correct folding and stability, as well as their transport through the secretory transport. Changes in N- and O-linked glycans have been associated with multiple pathological conditions including congenital disorders of glycosylation, inflammatory diseases and cancer. Glycoprotein glycosylation at the Golgi involves the coordinated action of hundreds of glycosyltransferases and glycosidases, which are maintained at the correct location through retrograde vesicle trafficking between Golgi cisternae. In this review, we describe the molecular machinery involved in vesicle trafficking and tethering at the Golgi apparatus and the effects of mutations in the context of glycan biosynthesis and human diseases.This publication has 153 references indexed in Scilit:
- COG5-CDG with a Mild Neurohepatic PresentationPublished by Springer Science and Business Media LLC ,2011
- Molecular organization of the COG vesicle tethering complexNature Structural & Molecular Biology, 2010
- Rab GEFs and GAPsCurrent Opinion in Cell Biology, 2010
- GOLPH3 Bridges Phosphatidylinositol-4- Phosphate and Actomyosin to Stretch and Shape the Golgi to Promote BuddingCell, 2009
- GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancerNature, 2009
- Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairingThe EMBO Journal, 2009
- Gerodermia osteodysplastica is caused by mutations in SCYL1BP1, a Rab-6 interacting golginNature Genetics, 2008
- Role of the conserved oligomeric Golgi (COG) complex in protein glycosylationCarbohydrate Research, 2008
- Golgi Localization of Glycosyltransferases Requires a Vps74p OligomerDevelopmental Cell, 2008
- Molecular and clinical characterization of a Moroccan Cog7 deficient patientMolecular Genetics and Metabolism, 2007