TLR2 antagonism attenuates the hippocampal neuronal damage in a murine model of sleep apnea via inhibiting neuroinflammation and oxidative stress
- 1 December 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Sleep and Breathing
- Vol. 24 (4), 1613-1621
- https://doi.org/10.1007/s11325-020-02030-3
Abstract
Background Obstructive sleep apnea (OSA) in humans chronically promotes the neuronal damage in the hippocampus. Toll-like receptor 2 (TLR2) is pivotal for the development of numerous hippocampal diseases. Chronic intermittent hypoxia (CIH) is a prominent feature of OSA. Here in our study, the effects of TLR2 antagonism on the neural damage elicited by CIH were examined. Methods Ortho-vanillin (O-vanillin) is an inhibitor of TLR2. Adult male mice were subjected to 8 h of intermittent hypoxia per day with or without O-vanillin for 28 days. Neuronal damage, the number of microglia, the interaction of TLR2 with its adapter protein myeloid differentiation factor 88 (MYD88), the expressions of inflammatory cytokines, and the oxidative stress were observed. Results O-vanillin inhibited the increased interaction of TLR2 and MyD88, the activation of NF kappa B, the aggregation of microglia, the overexpression of proinflammatory agents, the elevation of oxidative stress, and hippocampal neuron cell apoptosis induced by CIH. Conclusions Our experiments indicate that TLR2 antagonism may alleviate the hippocampal neuronal damage caused by CIH via inhibiting neuroinflammation and oxidative stress.Funding Information
- National Natural Science Foundation of China (81700089)
This publication has 45 references indexed in Scilit:
- Intermittent hypoxia from obstructive sleep apnea may cause neuronal impairment and dysfunction in central nervous system: the potential roles played by microgliaNeuropsychiatric Disease and Treatment, 2013
- VIP Gene Deletion in Mice Causes Cardiomyopathy Associated with Upregulation of Heart Failure GenesPLOS ONE, 2013
- Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microgliaNature Communications, 2013
- TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and ReperfusionMediators of Inflammation, 2013
- Chronic intermittent hypoxia-induced deficits in synaptic plasticity and neurocognitive functions: a role for brain-derived neurotrophic factorActa Pharmacologica Sinica, 2012
- Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluationNeuropharmacology, 2010
- Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in a rat model of neuropathic painPhytotherapy Research, 2009
- Manganese superoxide dismutase protects mouse cortical neurons from chronic intermittent hypoxia-mediated oxidative damageNeurobiology of Disease, 2007
- Toll-like receptor 2 mediates CNS injury in focal cerebral ischemiaJournal of Neuroimmunology, 2007
- Structural basis of long-term potentiation in single dendritic spinesNature, 2004