Anti-Cancer Effects of Huaier on Prostate Cancer; miRNA-Mediated Transcription Control Induced Both Inhibition of Active Progression and Prevention of Relapse
Prostate cancer is classified as mild malignant tumor, since the growth is slow, and also the early detection and monitoring of PSA and other cancer cell-specific markers are available among the target population in walk-in clinic even effect the bones and lymph nodes, it requires long term treatments which significantly decrease the lifespan in patients. Trametes robiniophila Murr (Huaier) has proved broad spectrum anti-cancer effects, which initiates the recovery of damaged bio physiological functions in the end by dose-dependent manner which proved the molecular basis of Huaier effects by total RNA and small non-coding RNA sequencing (“genome-scope” project) and that is based on the rescue of the disrupted transcriptional control based on individual capability and flexibility of genomic potential. Here we focused to show MEGA-DATA genome analysis results on inhibition of active progression in cancer in situ, and also prevents relapse of prostate cancer. Total sequencing of RNAs revealed massive SNP variances (average 89,473SNP variances per individual), however, it is unlikely that specific type variants influenced to the malignancy, process, and prognosis. On the other hand, the significant up-regulation and alteration of major ontogenesis and tumor suppressor genes were detected in transcribed genes, especially in altered (normalized) NFkB, TGFb, BRCA2 and p53 genes and their leading signaling pathways. These genetic alterations in transcriptomes were based on miRNA-mediated transcriptional control as reported drugs have not shown any effect. Thus, the present study provides the safe and effective treatment to prevent and inhibit prostate cancer progression, and also to maintain homeostasis in a long-range of stressful human life without excessive medical treatments.