THE ROLE OF VASCULAR HOMEOSTASIS IN WOMEN WITH INFERTILITY TREATED WITH ASSISTED REPRODUCTIVE TECHNOLOGIES AND WITH CONCOMITANT INTRAHEPATIC CHOLESTASIS
Open Access
- 20 February 2021
- journal article
- Published by RS Global Sp. z O.O. in World Science
Abstract
Intrahepatic cholestasis of pregnancy (idiopathic jaundice of pregnancy, recurrent familial jaundice of pregnancy) is a benign familial disease manifesting itself in the gestational period in itching and (or) jaundice. As a rule, the disease is observed in the 3rd trimester of pregnancy, that is in the 28th-30th week, and may disappear by itself a few days after labor and recur during future pregnancies.The aim of this research is to study the role and factors of vascular homeostasis regulation in women with infertility treated with assisted reproductive technologies (ART) and with concomitant intrahepatic cholestasis. Intrahepatic cholestasis is characterized by the damage of endothelial cells of hepatic sinusoids, changes in the intrahepatic hemodynamics, increased production of cytokines and free radicals. The processes of angiogenesis in the liver are also closely connected with the functional capacity of endothelium. The L-arginine level in blood was measured using the photometric method based. The homocysteine level was measured by the enzymatic cycling method. To measure the level of placental growth factor (PGF) in blood plasma samples, we used the immunochemical method.The research has found especially severe complications in the course of pregnancy after ART in those women with intrahepatic cholestasis whose placentas developed under the conditions of endothelial dysfunction from the very beginning of pregnancy.So, these factors may be early prognostic markers of severe obstetrical and perinatal disorders in women with induced pregnancy and hepatobiliary disorders.Keywords
This publication has 11 references indexed in Scilit:
- Efficacy of Ursodeoxycholic Acid in Treating Intrahepatic Cholestasis of Pregnancy: A Meta-analysisGastroenterology, 2012
- Decreased 1,25‐dihydroxy vitamin D levels in women with intrahepatic cholestasis of pregnancyActa Obstetricia et Gynecologica Scandinavica, 2010
- Genetic Determinants of Drug-induced Cholestasis and Intrahepatic Cholestasis of PregnancySeminars in Liver Disease, 2010
- Intrahepatic Cholestasis of Pregnancy and Neonatal Respiratory Distress SyndromePEDIATRICS, 2006
- Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: A population-based studyJournal of Hepatology, 2006
- Intrahepatic cholestasis of pregnancy — A heterogeneous group of pregnancy-related disorders?Journal of Hepatology, 2006
- Cholestasis of PregnancyThe Journal of Perinatal & Neonatal Nursing, 2005
- Intrahepatic cholestasis of pregnancyClinics in Liver Disease, 2004
- Bile acids and progesterone metabolites intrahepatic cholestasis of pregnancyAnnals of Medicine, 2000
- INTRAHEPATIC CHOLESTASIS OF PREGNANCYClinics in Liver Disease, 1999