Treatment of knee osteoarthritis by intra-articular injection of concentrated autologous adipose tissue: a twenty four month follow-up study
- 4 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in International Orthopaedics
- Vol. 45 (3), 627-633
- https://doi.org/10.1007/s00264-020-04923-0
Abstract
Purpose To evaluate the safety and efficacy of autologous concentrated adipose tissue for the treatment of knee OA. Methods Eighty-seven patients with knee arthritis from grade 1 to 3, according to Kellgren-Lawrence scale, have been treated with knee arthroscopy and successive intra-articular injection of concentrated adipose tissue. The efficacy of the treatment has been evaluated by the Knee Society Score, Lysholm Score, Forgotten Joint Score, Knee Injury and Osteoarthritis Outcome Score and Noise Reporting Scale. Results A total of 78/87 patients concluded the study. Overall, the patients were satisfied with the intervention and a significant reduction of the pain was observed in 67 patients, while the others did not report any change in pain severity or worsening. A statistically significant improvement was observed in the considered orthopaedic index, and no major adverse effects were described. The first week after the intervention, most patients reported knee swelling. Five patients failed because they underwent knee replacement surgery between five and nine months from treatment. Conclusions In patients with knee OA, a single intra-articular injection of autologous adipose tissue reduced knee pain, stiffness, improved knee function and quality of life without severe complications.Keywords
Funding Information
- Compagnia di San Paolo
- Fondazione CRT
- Banca d'Italia
- Fondazione Ricerca Molinette
This publication has 32 references indexed in Scilit:
- Intra‐Articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee: A Proof‐of‐Concept Clinical TrialThe International Journal of Cell Cloning, 2014
- A New Nonenzymatic Method and Device to Obtain a Fat Tissue Derivative Highly Enriched in Pericyte-Like Elements by Mild Mechanical Forces from Human LipoaspiratesCell Transplantation, 2013
- MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune ModulationStem Cells International, 2013
- Comparison of Fixed and Mobile-Bearing Total Knee Arthroplasty at a Mean Follow-up of 116 MonthsJournal of Bone and Joint Surgery, 2013
- Autologous Fat Grafts Harvested and Refined by the Coleman Technique: A Comparative StudyPlastic and Reconstructive Surgery, 2008
- Epidemiology of OsteoarthritisRheumatic Disease Clinics of North America, 2008
- Comparison of mesenchymal tissues-derived stem cells for in vivo chondrogenesis: suitable conditions for cell therapy of cartilage defects in rabbitCell and tissue research, 2008
- Tumescent liposuction: A reviewJournal of Cutaneous and Aesthetic Surgery, 2008
- Fat Grafting to the Breast Revisited: Safety and EfficacyPlastic and Reconstructive Surgery, 2007
- Mesenchymal stem cells as trophic mediatorsJournal of Cellular Biochemistry, 2006