Preclinical Models for the Study of Lung Cancer Pathogenesis and Therapy Development
- 13 September 2021
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Medicine
- Vol. 11 (12), a037820
- https://doi.org/10.1101/cshperspect.a037820
Abstract
Experimental preclinical models have been a cornerstone of lung cancer translational research. Work in these model systems has provided insights into the biology of lung cancer subtypes and their origins, contributed to our understanding of the mechanisms that underlie tumor progression, and revealed new therapeutic vulnerabilities. Initially patient-derived lung cancer cell lines were the main preclinical models available. The landscape is very different now with numerous preclinical models for research each with unique characteristics. These include genetically engineered mouse models (GEMMs), patient-derived xenografts (PDXs) and three-dimensional culture systems (“organoid” cultures). Here we review the development and applications of these models and describe their contributions to lung cancer research.This publication has 273 references indexed in Scilit:
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