VEGF Genotype and Allele Frequency of Diabetes Mellitus and Diabetic retinopathy in Lahore, Pakistan
Open Access
- 31 December 2022
- journal article
- Published by CrossLinks International Publishers in Futuristic Biotechnology
Abstract
Diabetic retinopathy is characterized as basement membrane (BM) thickening, pericyte loss, endothelial cell (EC) dysfunction, microaneurysms, microvascular infarcts and neovascularization in a patient with diabetic retinopathy. Objectives: To determine the VEGF genotype and allele frequency of diabetes mellitus and diabetic retinopathy in Lahore, Pakistan. Methods: A total of 100 blood samples were taken including diabetes mellitus (50) and diabetic retinopathy patients (50). Diseased and control subjects were selected for blood sampling. Demographic and clinical characteristics was evaluated. The BMI, HbA1c and the blood pressure of both groups were also examined. The VEGF genotype and allele frequency of diabetes mellitus and diabetic retinopathy was done. The statistical analysis was done by chi-square test and SPSS to study significant differences in control and diabetic retinopathy subjects. Results: The normal estimation of DM group was 46.18 ± 1.23 years while of DR class was 52.86 ± 1.36 years. The mean value of BMI of DM group was 26.0±0.62 while of DR group was 26.57±0.70. DD genetic mutation was substantially higher in diabetic retinopathy bunch (pConclusions: This study concluded that Vascular endothelial growth factor gene was detected in both group of diabetes. In retinopathy people with T2DM the substantial elevated VEGF DD genetic variation was seen relative to retinopathy people without diabetes.Keywords
This publication has 19 references indexed in Scilit:
- Global Prevalence and Major Risk Factors of Diabetic RetinopathyDiabetes Care, 2012
- Serum VEGF and CFH in Exudative Age-Related Macular DegenerationCurrent Eye Research, 2010
- Epidemiology of Type 1 DiabetesEndocrinology and Metabolism Clinics of North America, 2010
- Pakistan National Diabetes Survey: Prevalence of glucose intolerance and associated factors in the Punjab Province of PakistanPrimary Care Diabetes, 2010
- Global estimates of the prevalence of diabetes for 2010 and 2030Diabetes Research and Clinical Practice, 2010
- Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart diseaseGenome Medicine, 2009
- Fatores de risco para retinopatia diabéticaArchives of Endocrinology and Metabolism, 2008
- Genetic Factors in Diabetic NephropathyClinical Journal of the American Society of Nephrology, 2007
- Type 1 diabetes: recent developmentsBMJ, 2004
- Vascular endothelial growth factors and angiogenesis in eye diseaseProgress in Retinal and Eye Research, 2003