The clinical characteristics and outcomes of heart failure patient with chronic obstructive pulmonary disease from the Japanese community-based registry
- 1 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Heart and Vessels
- Vol. 36 (2), 223-234
- https://doi.org/10.1007/s00380-020-01675-0
Abstract
Both heart failure (HF) and chronic obstructive pulmonary disease (COPD) are common diseases, but few studies have assessed the relationship between COPD and outcomes in patients with acute HF, especially in relation to age or ejection fraction (EF). The Kitakawachi Clinical Background and Outcome of Heart Failure Registry was a prospective, multicenter, community-based cohort and enrolled a total of 1,102 patients with acute HF between 2015 and 2017 in this study. The primary endpoint was defined as a composite endpoint that included all-cause mortality and hospitalization for HF. We stratified patients into two groups: those aged >= 80 years (elderly) and < 80 years (nonelderly). HF with preserved EF (HFpEF) was defined as EF >= 50%, whereas HF with reduced ejection fraction (HFrEF) was defined as EF < 50%. A total of 159 patients (14.4%) with COPD and 943 patients (83.6%) without COPD were included. COPD was found to be independently associated with a higher risk of the composite endpoint (adjusted hazard ratio: 1.42, 95% confidence interval: 1.14-1.77;p = 0.003). During a subgroup analysis, COPD was exposed as an independent risk factor of the composite endpoint in nonelderly patients; however, there was not such a finding observed among elderly patients. Separately, there was a significant association with COPD and the composite endpoint in patients with HFpEF. COPD showed a significantly higher risk of the composite endpoint after discharge in acute HF. However, this heightened risk was observable only in the subgroup of nonelderly patients and those of HFpEF.Funding Information
- Nakajima Steel Pipe Company Limited
This publication has 44 references indexed in Scilit:
- Clinical characteristics, response to exercise training, and outcomes in patients with heart failure and chronic obstructive pulmonary disease: Findings from Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION)American Heart Journal, 2013
- Impact of Noncardiac Comorbidities on Morbidity and Mortality in a Predominantly Male Population With Heart Failure and Preserved Versus Reduced Ejection FractionJournal of the American College of Cardiology, 2012
- Characteristics and Outcomes of Very Elderly Patients After First Hospitalization for Heart FailureCirculation: Heart Failure, 2011
- Heart failure and chronic obstructive pulmonary disease: diagnostic pitfalls and epidemiologyEuropean Journal of Heart Failure, 2009
- Clinical Characteristics and Outcome of Hospitalized Patients With Heart Failure in Japan Rationale and Design of Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)Circulation Journal, 2006
- Under-use of beta-blockers in patients with ischaemic heart disease and concomitant chronic obstructive pulmonary diseaseQJM: An International Journal of Medicine, 2005
- Smoking Cessation and Mortality from Cardiovascular Disease among Japanese Men and Women: The JACC StudyAmerican Journal of Epidemiology, 2005
- Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control studyThe Lancet, 2004
- ACE in COPD: a therapeutic target?Thorax, 2003
- The epidemiology of heart failure: The Framingham StudyJournal of the American College of Cardiology, 1993