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Prognostic significance and biological function of Lamina-associated polypeptide 2 in non-small-cell lung cancer

Chang Liu, Hui Yu, Xuxia Shen, Jie Qiao, Xianghua Wu, Jianhua Chang, Xunxia Zhu, Jialei Wang, Xiaoyong Shen
Published: 16 May 2019
OncoTargets and Therapy , Volume 12, pp 3817-3827; doi:10.2147/OTT.S179870

Abstract: Purpose: Lamina-associated polypeptide 2 (LAP2; encoded by TMPO), is a nuclear protein that may affect chromatin regulation and gene expression through dynamically binding to nuclear lamin. TMPO (LAP2) plays dual roles of either suppressing or promoting proliferation of cells, depending on the status of the cell. It has been reported that TMPO is up-regulated in various cancer types. However, its function in lung cancer has not been studied yet.
Keywords: non-small-cell lung cancer / Oncogene / Lap2 / prognostic factor / Tmpo

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