Serum Lactate Could Predict Mortality in Patients With Spontaneous Subarachnoid Hemorrhage in the Emergency Department
Open Access
- 4 September 2020
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Neurology
Abstract
Background:Serum lactate is a useful biomarker for prediction of mortality in critically ill patients. The purpose of this study was to identify if serum lactate could be used as a biomarker for predicting mortality in patients with subarachnoid hemorrhage (SAH) in the emergency department. Methods:This retrospective study enrolled 189 patients. Baseline demographic data and clinical characteristics of patients were obtained from medical record review. Multiple logistic regression analysis was performed to determine predictor variables significantly associated with mortality. Receiver operating characteristic (ROC) curve analysis was used to evaluate the performance of variables for mortality prediction in SAH. Results:Using multivariate logistic regression analysis, age [OR 1.05; 95% confidence interval (CI) 1.00-1.10;p= 0.037], Hunt and Hess scale score (OR 3.29; 95% CI 1.62-6.70;p= 0.001), serum lactate level (OR 1.33; 95% CI 1.03-1.74;p= 0.032), and serum glucose level (OR 1.01; 95% CI 1.00-1.02;p= 0.049) predicted overall mortality in SAH. The area under the ROC curve (AUC) value for the use of serum lactate level to predict mortality in SAH was 0.815 (95% CI 0.753-0.868) (p< 0.001). Conclusion:Serum lactate may be a useful biomarker for the early prediction of mortality in SAH patients in the emergency department.Funding Information
- National Research Foundation of Korea
This publication has 35 references indexed in Scilit:
- Clinical use of lactate monitoring in critically ill patientsAnnals of Intensive Care, 2013
- Guidelines for the Management of Aneurysmal Subarachnoid HemorrhageStroke, 2012
- Lactate as a hemodynamic marker in the critically illCurrent Opinion in Critical Care, 2012
- An evaluation of serial blood lactate measurement as an early predictor of shock and its outcome in patients of trauma or sepsisIndian Journal of Critical Care Medicine, 2009
- Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trendsJournal of Neurology, Neurosurgery & Psychiatry, 2007
- Prediction of Symptomatic Vasospasmafter Subarachnoid Hemorrhage: The Modified Fisher ScaleNeurosurgery, 2006
- Increased Sympathetic Nervous Activity in Patients With Nontraumatic Subarachnoid HemorrhageStroke, 2000
- Linkage of aerobic glycolysis to sodium-potassium transport in rat skeletal muscle. Implications for increased muscle lactate production in sepsis.JCI Insight, 1996
- Catecholamine response to a gradual increase of intracranial pressureJournal of Neurosurgery, 1993
- A universal subarachnoid hemorrhage scale: report of a committee of the World Federation of Neurosurgical Societies.Journal of Neurology, Neurosurgery & Psychiatry, 1988