Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes

Abstract

Quiz Ref ID Epigenetics refers to a process whereby chromatin undergoes chemical modification in response to its environment, affecting transcription. One such modification is acetylation of lysine residues on histone proteins. Bromodomain and extraterminal proteins are a family of epigenetic “readers” that detect and bind to acetylated lysine residues, thereby forming molecular scaffolds between chromatin and transcriptional machinery.^1-4 Recruitment of bromodomain and extraterminal proteins may enhance the expression of genes that drive maladaptive responses in atherosclerosis, including inflammation, oxidation, complement activation, and thrombogenesis.^5,6