Chemical and mechanical characterization of hyaluronic acid hydrogel cross‐linked with polyethylen glycol and its use in dermatology
- 1 July 2020
- journal article
- research article
- Published by Hindawi Limited in Dermatologic Therapy
- Vol. 33 (4), e13747
- https://doi.org/10.1111/dth.13747
Abstract
Hydrogels based on hyaluronic acid are used to restore volume, hydration, and skin tone, as well as to correct scars, asymmetries or defects of the soft tissue. Hyaluronic acid is often chemically crosslinked with different crosslinking agents in order to improve its mechanical and biological properties. Here we focused on defining the chemical and mechanical characterization of a new hydrogel with specific characteristics: hyaluronic acid polyethylene glycol (PEG)-crosslinked with a high concentration of hyaluronic acid (28 mg/mL), manufactured by MatexLab Spa, via Carlo Urbani 2, ang Via Enrico Fermi, Brindisi, Italy. We made a quantitative and qualitative analysis of the content of sodium hyaluronate in the hydrogel after polymerization and sterilization processes and also evaluated histologically the bio integration of these hydrogels in the cutaneous soft tissues. The results suggest that hyaluronic acid hydrogel PEG-crosslinked have great bio integration, great chemical and mechanical properties, compared with other products available on the market, that are cross-linked with different cross-linking agents. The nontoxicity and nonimmunogenicity of PEG guarantee the lack of allergic and immunological reactions. The PEG-crosslinking technology guarantees a high duration time of the implanted hydrogel because of more resistant physiological degradation.Keywords
This publication has 31 references indexed in Scilit:
- Hyaluronic Acid Dermal Fillers: Safety and Efficacy for the Treatment of Wrinkles, Aging Skin, Body Sculpturing and Medical ConditionsClinical Medicine Reviews in Therapeutics, 2011
- Hyaluronan Synthesis Is Inhibited by Adenosine Monophosphate-activated Protein Kinase through the Regulation of HAS2 Activity in Human Aortic Smooth Muscle CellsOnline Journal of Public Health Informatics, 2011
- The Activity of Hyaluronan Synthase 2 Is Regulated by Dimerization and UbiquitinationOnline Journal of Public Health Informatics, 2010
- PEG and PEG conjugates toxicity: towards an understanding of the toxicity of PEG and its relevance to PEGylated biologicalsPublished by Springer Science and Business Media LLC ,2009
- The third dimension in facial rejuvenation: a reviewJournal of Cosmetic Dermatology, 2006
- PEGylated Proteins: Evaluation of Their Safety in the Absence of Definitive Metabolism StudiesDrug Metabolism and Disposition, 2006
- Degradative Action of Reactive Oxygen Species on HyaluronanBiomacromolecules, 2006
- Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic productsToxicology, 2005
- Safety of Poly(ethylene glycol) and Poly(ethylene glycol) DerivativesPublished by American Chemical Society (ACS) ,1997
- A modified uronic acid carbazole reactionAnalytical Biochemistry, 1962