Hydroglycerolic Solvent and Ultrasonication Pretreatment: A Green Blend for High-Efficiency Extraction of Salvia fruticosa Polyphenols
Open Access
- 13 June 2020
- journal article
- research article
- Published by MDPI AG in Sustainability
- Vol. 12 (12), 4840
- https://doi.org/10.3390/su12124840
Abstract
Salvia fruticosa Miller, also known as Cretan or Greek sage, is a medicinal plant with significant biological properties, which are largely ascribed to its polyphenolic composition, but there is to-date a scarcity of green and sustainable processes for efficient polyphenol extraction from this plant. The objective of this study was the implementation of an extraction process that would combine a green solvent based on glycerol, a biodiesel industry by-product, and ultrasonication pretreatment. Ultrasonication for 40 min followed by stirred-tank extraction was shown to provide significantly higher total polyphenol yield than mere stirred-tank extraction, while kinetics indicated 50 °C as the most favorable temperature, with the yield being 92 mg gallic acid equivalents (GAE) per g dry mass. Comparison of this method with a previously developed one that used methyl β-cyclodextrin revealed that the extracts obtained had similar antioxidant activity, and yield in major polyphenols including luteolin 7-O-glucuronide and rosmarinic acid was virtually equal. The current process is proposed as a sustainable and effective methodology for the generation of polyphenol-enriched extracts from S. fruticosa, which could be used as effective food antioxidants/antimicrobials and/or cosmetic constituents.Keywords
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