Role of prothrombin 19911 A>G polymorphism, blood group and male gender in patients with venous thromboembolism: Results of a German cohort study
Open Access
- 27 June 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Thrombosis and Thrombolysis
- Vol. 51 (2), 494-501
- https://doi.org/10.1007/s11239-020-02169-6
Abstract
The role of the A>G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous thromboembolism [VTE] is still unclear. To evaluate the presence of the F2 polymorphism in VTE patients compared to healthy blood donors and to adjust the results for common inherited thrombophilias [IT], age at onset and blood group [BG], and to calculate the risk of VTE recurrence. We investigated 1012 Caucasian patients with a diagnosis of VTE for the presence of the F2 rs3136516 polymorphism and compared these with 902 healthy blood donors. Odds ratios [OR] together with their 95% confidence intervals were calculated adjusted for F5 at rs6025, F2 at rs1799963, blood group, age and gender. In addition, we evaluated the risk of recurrent VTE during patient follow-up calculating hazard ratios [HR] together with their 95% CI. Compared with the AA wildtype, the F2 GG and AG genotypes (rs3136516) were associated with VTE (OR 1.48 and 1.45). The OR in F5 carriers compared to controls was 5.68 and 2.38 in patients with F2 (rs1799963). BG “non-O” was significantly more often diagnosed in patients compared to BG “O” (OR 2.74). VTE recurrence more often occurred in males (HR 2.3) and in carriers with combined thrombophilia (HR 2.11). Noteworthy, the rs3136516 polymorphism alone was not associated significantly with recurrence. In Caucasian patients with VTE the F2 GG/GA genotypes (rs3136516) were moderate risk factors for VTE. Recurrence was associated with male gender and combined thrombophilia.Keywords
Funding Information
- Förderverein “Schlaganfall und Thrombosen im Kindesalter e.V.”
- Interdisziplinäres Zentrum für klinische Forschung (IZKF: CRA01-09)
- Gesellschaft für Thrombose und Hämostaseforschung/ Society of Thrombosis and Hemostasis Research“ (GTH 2016)
This publication has 32 references indexed in Scilit:
- Inherited thrombophilia in children with venous thromboembolism and the familial risk of thromboembolism: an observational studyBlood, 2012
- Antithrombotic Therapy in Neonates and Children: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice GuidelinesSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 2012
- Predicting the risk of venous thromboembolism recurrenceAmerican Journal of Hematology, 2012
- Risk of recurrence after venous thromboembolism in men and women: patient level meta-analysisBMJ, 2011
- Role of endogenous testosterone concentration in pediatric strokeAnnals of Neurology, 2009
- Recurrence Rate After a First Venous Thrombosis in Patients With Familial ThrombophiliaArteriosclerosis, Thrombosis, and Vascular Biology, 2005
- Prothrombin A19911G and G20210A polymorphisms' role in thrombosisBritish Journal of Haematology, 2002
- Blood coagulationThe Lancet, 2000
- Mutation in blood coagulation factor V associated with resistance to activated protein CNature, 1994
- A Population-Based Perspective of the Hospital Incidence and Case-Fatality Rates of Deep Vein Thrombosis and Pulmonary EmbolismArchives of Internal Medicine, 1991