Impaired oxidative-antioxidative balance during migraine attack
Open Access
- 17 February 2019
- journal article
- research article
- Published by Biomedical Research and Therapy in Biomedical Research and Therapy
- Vol. 6 (2), 2996-3002
- https://doi.org/10.15419/bmrat.v6i2.522
Abstract
Background: Recent evidence has suggested that oxidative stress may play a role in the pathophysiology of migraine. In this study, we aimed to evaluate the oxidative-antioxidative status in sera of migraine patients from an Iranian population during migraine attacks. Methods: This study recruited 46 migraine patients with or without aura and 45 sex- and age-matched healthy controls. The levels of protein carbonyl (PC), malondialdehyde (MDA) and total oxidants status (TOS) were measured as the indicators of oxidative stress. The levels of total thiols (T-SH), reduced glutathione (GSH) and total antioxidant capacity (TAC) were determined as markers of antioxidant status. Oxidative stress index (OSI) was calculated by dividing TOS to TAC. Results: The serum levels of MDA (4.10 +/- 0.70 vs. 3.20 +/- 0.62, P = 0.003), TOS (18.46 +/- 4.06 vs. 16.21 +/- 3.67, P = 0.007) and OSI (1.54 +/- 0.60 vs. 1.22 +/- 0.46, P = 0.006) were significantly higher in migraine group compared to controls, however, no statistically significant differences of PC levels were found between migraine patients and controls (0.615 +/- 0.161 vs. 0.517 +/- 0.126, P = 0.1). In contrast, the levels of T-SH (273 +/- 51.71 vs. 310.88 +/- 53.32, P = 0.001), GSH (28.08 +/- 6.20 vs. 32.13 +/- 5.8, P = 0.002) and TAC (1.27 +/- 0.226 vs. 1.41 +/- 0.26, P = 0.01) were significantly lower in migraine patients compared to healthy controls. Conclusion: Our study showed higher levels of oxidative stress and lower levels of antioxidant status in migraine group compared to controls, which indicates the possible role of oxidative stress in triggering migraine attacks.Keywords
This publication has 21 references indexed in Scilit:
- Pathophysiological basis of migraine prophylaxisProgress in Neurobiology, 2009
- Increased nitric oxide stress is associated with migraineCephalalgia, 2009
- The role of antioxidants and antioxidant-related enzymes in protective responses to environmentally induced oxidative stressMutation Research - Genetic Toxicology and Environmental Mutagenesis, 2009
- Comparison of oxidative stress among migraineurs, tension-type headache subjects, and a control groupAnnals of Indian Academy of Neurology, 2009
- Hydrogen peroxide is a novel mediator of inflammatory hyperalgesia, acting via transient receptor potential vanilloid 1-dependent and independent mechanismsPain, 2009
- Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative StressJournal of Neuroscience, 2008
- Free radicals and antioxidants in normal physiological functions and human diseaseThe International Journal of Biochemistry & Cell Biology, 2007
- Neuronal Signal Substances as Biomarkers of MigraineHeadache: The Journal of Head and Face Pain, 2006
- Use of a Pine Bark Extract and Antioxidant Vitamin Combination Product as Therapy for Migraine in Patients Refractory to Pharmacologic MedicationHeadache: The Journal of Head and Face Pain, 2006
- Reactive oxygen species: influence on cerebral vascular toneJournal of Applied Physiology, 2006