Regional COVID-19 spread despite expected declines: how mitigation is hindered by spatio-temporal variation in local control measures
Preprint
- 19 July 2020
- preprint
- other
- Published by Cold Spring Harbor Laboratory
Abstract
Successful public health regimes for COVID-19 push below unity long-term global Rt –the average number of secondary cases caused by an infectious individual. Most assessments use local information. Populations differ in Rt, amongst themselves and over time. We use a SIR model for two populations to make the conceptual point that even if each locality averages Rt < 1, the overall epidemic can still grow, provided these populations have asynchronous variation in transmission, and are coupled by movement of infectious individuals. This emergent effect in pandemic dynamics instantiates “Parrondo’s Paradox,” -- an entity comprised of distinct but interacting units can behave qualitatively differently than each part on its own. For effective COVID-19 disease mitigation strategies, it is critical that infectious individuals moving among locations be identified and quarantined. This does not warrant indiscriminate prevention of movement, but rather rational, targeted testing and national coordination.Keywords
This publication has 10 references indexed in Scilit:
- The challenges of modeling and forecasting the spread of COVID-19Proceedings of the National Academy of Sciences of the United States of America, 2020
- Substantial undocumented infection facilitates the rapid dissemination of novel coronavirus (SARS-CoV-2)Science, 2020
- Spread and dynamics of the COVID-19 epidemic in Italy: Effects of emergency containment measuresProceedings of the National Academy of Sciences of the United States of America, 2020
- The exacerbation of Ebola outbreaks by conflict in the Democratic Republic of the CongoProceedings of the National Academy of Sciences of the United States of America, 2019
- Paradoxical Survival: Examining the Parrondo Effect across BiologyBioEssays, 2019
- THE INFLATIONARY EFFECTS OF ENVIRONMENTAL FLUCTUATIONS ENSURE THE PERSISTENCE OF SINK METAPOPULATIONSEcology, 2007
- Temporal Autocorrelation Can Enhance the Persistence and Abundance of Metapopulations Comprised of Coupled SinksThe American Naturalist, 2005
- Persistent colonization and the spread of antibiotic resistance in nosocomial pathogens: Resistance is a regional problemProceedings of the National Academy of Sciences of the United States of America, 2004
- Losing strategies can win by Parrondo's paradoxNature, 1999
- Populations can persist in an environment consisting of sink habitats onlyProceedings of the National Academy of Sciences of the United States of America, 1998