The epidemiology of hepatitis delta virus infection in Cameroon
- 6 January 2020
- Vol. 69 (7), 1294-1300
- https://doi.org/10.1136/gutjnl-2019-320027
Abstract
Objective To investigate the distribution and risk factors of hepatitis delta virus (HDV) infection in Cameroon. Design We tested for hepatitis B virus (HBV) surface antigen (HBsAg) and anti-HDV antibody 14 150 samples collected during a survey whose participants were representative of the Cameroonian adult population. The samples had already been tested for hepatitis C virus and HIV antibodies. Results Overall, 1621/14 150 (weighted prevalence=11.9%) participants were HBsAg positive, among whom 224/1621 (10.6%) were anti-HDV positive. In 2011, the estimated numbers of HBsAg positive and HDV seropositives were 1 160 799 and 122 910 in the 15–49 years age group, respectively. There were substantial regional variations in prevalence of chronic HBV infection, but even more so for HDV (from 1% to 54%). In multivariable analysis, HDV seropositivity was independently associated with living with an HDV-seropositive person (OR=8.80; 95% CI: 3.23 to 24.0), being HIV infected (OR=2.82; 95% CI: 1.32 to 6.02) and living in the South (latitude Conclusion We found evidence for effective intra-household transmission of HDV in Cameroon. We also identified large differences in prevalence between regions, with cases concentrated in forested areas close to the Equator, as described in other tropical areas. The reasons underlying these geographical variations in HDV prevalence deserve further investigation.Keywords
Funding Information
- Agence Nationale de Recherches sur le Sida et les Hépatites Virales (12289)
This publication has 32 references indexed in Scilit:
- Characterization of Hepatitis Delta Virus in Sub-Saharan AfricaJournal of Clinical Microbiology, 2014
- Hepatitis B, C, and D and HIV Infections among Immigrants from Equatorial Guinea Living in SpainThe American Journal of Tropical Medicine and Hygiene, 2013
- High Prevalence and Predominance of Hepatitis Delta Virus Genotype 1 Infection in CameroonJournal of Clinical Microbiology, 2011
- Role of social networks in shaping disease transmission during a community outbreak of 2009 H1N1 pandemic influenzaProceedings of the National Academy of Sciences of the United States of America, 2011
- Prevalence and Molecular Diversity of Hepatitis B Virus and Hepatitis Delta Virus in Urban and Rural Populations in Northern Gabon in Central AfricaJournal of Clinical Microbiology, 2009
- Approximate Bayesian Inference for Latent Gaussian models by using Integrated Nested Laplace ApproximationsJournal of the Royal Statistical Society Series B: Statistical Methodology, 2009
- Bayesian Inference in Gaussian Model-based GeostatisticsGeographical and Environmental Modelling, 2002
- Fulminant hepatitis with microvesicular steatosis (a histologic comparison of cases occurring in Brazil - Labrea hepatitis - and in central Africa - Bangui hepatitis)Revista da Sociedade Brasileira de Medicina Tropical, 1992
- On Chi-Squared Tests for Multiway Contingency Tables with Cell Proportions Estimated from Survey DataThe Annals of Statistics, 1984
- The Analysis of Categorical Data From Complex Sample Surveys: Chi-Squared Tests for Goodness of Fit and Independence in Two-Way TablesJournal of the American Statistical Association, 1981