New Haloterpenes from the Marine Red Alga Laurencia papillosa: Structure Elucidation and Biological Activity
Open Access
- 14 January 2021
- journal article
- research article
- Published by MDPI AG in Marine Drugs
- Vol. 19 (1), 35
- https://doi.org/10.3390/md19010035
Abstract
Analysis of the air-dried marine red alga Laurencia papillosa, collected near Ras-Bakr at the Suez gulf (Red Sea) in Egypt delivered five new halogenated terpene derivatives: aplysiolic acid (1), 7-acetyl-aplysiol (2), aplysiol-7-one (3), 11,14-dihydroaplysia-5,11,14,15-tetrol (5a), and a new maneonene derivative 6, named 5-epi-maneolactone. The chemical structures of these metabolites were characterized employing spectroscopic methods, and the relative and absolute configurations were determined by comparison of experimental and ab initio-calculated NMR, NOE, ECD, and ORD data, and by X-ray diffraction of 2 and 6. The antimicrobial activities of the crude extract and compounds 1–3, 5a and 6 were studied.Keywords
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