Tissue texture extraction in indocyanine green fluorescence imaging for breast-conserving surgery
Open Access
- 11 February 2021
- journal article
- research article
- Published by IOP Publishing in Journal of Physics D: Applied Physics
- Vol. 54 (19), 194005
- https://doi.org/10.1088/1361-6463/abe571
Abstract
A two-camera fluorescence system for indocyanine green (ICG) signal detection has been developed and tested in a clinical feasibility trial of 10 patients, with a resolution in the submillimetre scale. Immediately after systemic ICG injection, the two-camera system can detect ICG signals in vivo (~2.5 mg -1 or 3.2 10-6 M). Qualitative assessment has shown that the fluorescence signal does not always correlate with the cancer location in the surgical scene. Conversely, fluorescence image texture metrics when used with the logistic regression model yields good accuracy scores in detecting cancer. We have demonstrated that intraoperative fluorescence imaging for resection guidance is a feasible solution to tackle the current challenge of positive resection margins (PRM) in breast conserving surgery (BCS).Funding Information
- Greek Foundation for Education and European Culture
- Engineering and Physical Sciences Research Council [EPSRC] Impact Acceleration Account scheme)
- Imperial Confidence in Concept (ICiC) Joint Translational Fund (Imperial College’s Medical Research Council [MRC] Confidence in Concept fund
- Cancer Research UK (CRUK) Imperial Centre
- National Institute for Health Research (NIHR) Imperial Biomedical Research Centre
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