N-terminal pro-brain natriuretic peptide and sudden cardiac death in hypertrophic cardiomyopathy

Abstract
Objective Elevated levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with heart failure-related death in hypertrophic cardiomyopathy (HCM), but the relationship between NT-proBNP level and sudden cardiac death (SCD) in HCM remains undefined. Methods The study prospectively enrolled 977 unrelated patients with HCM with available NT-proBNP results who were prospectively enrolled and followed for 3.0±2.1 years. The Harrell’s C-statistic under the receiver operating characteristic curve was calculated to evaluate discrimination performance. A combination model was constructed by adding NT-proBNP tertiles to the HCM Risk-SCD model. The correlation between log NT-proBNP level and cardiac fibrosis as measured by late gadolinium enhancement (LGE) or Masson’s staining was analysed. Results During follow-up, 29 patients had SCD. Increased log NT-proBNP levels were associated with an increased risk of SCD events (adjusted HR 22.27, 95% CI 10.93 to 65.63, pConclusion NT-proBNP is an independent predictor of SCD in patients with HCM and may help with risk stratification of this disease.
Funding Information
  • National Natural Science Foundation of China (81470380, 81570276, 81670274, 81870286)
  • CAMS Innovation Fund for Medical Sciences (CAMS-I2M, 2016-I2M-1-015)

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