N-terminal pro-brain natriuretic peptide and sudden cardiac death in hypertrophic cardiomyopathy
- 24 December 2020
- Vol. 107 (19), 1576-1583
- https://doi.org/10.1136/heartjnl-2020-317701
Abstract
Objective Elevated levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are associated with heart failure-related death in hypertrophic cardiomyopathy (HCM), but the relationship between NT-proBNP level and sudden cardiac death (SCD) in HCM remains undefined. Methods The study prospectively enrolled 977 unrelated patients with HCM with available NT-proBNP results who were prospectively enrolled and followed for 3.0±2.1 years. The Harrell’s C-statistic under the receiver operating characteristic curve was calculated to evaluate discrimination performance. A combination model was constructed by adding NT-proBNP tertiles to the HCM Risk-SCD model. The correlation between log NT-proBNP level and cardiac fibrosis as measured by late gadolinium enhancement (LGE) or Masson’s staining was analysed. Results During follow-up, 29 patients had SCD. Increased log NT-proBNP levels were associated with an increased risk of SCD events (adjusted HR 22.27, 95% CI 10.93 to 65.63, pConclusion NT-proBNP is an independent predictor of SCD in patients with HCM and may help with risk stratification of this disease.Keywords
Funding Information
- National Natural Science Foundation of China (81470380, 81570276, 81670274, 81870286)
- CAMS Innovation Fund for Medical Sciences (CAMS-I2M, 2016-I2M-1-015)
This publication has 24 references indexed in Scilit:
- A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM Risk-SCD)European Heart Journal, 2013
- B-Type Natriuretic Peptide and Survival in Hypertrophic CardiomyopathyJournal of the American College of Cardiology, 2013
- Relation between serum N-terminal pro-brain natriuretic peptide and prognosis in patients with hypertrophic cardiomyopathyEuropean Heart Journal, 2013
- Standardized image interpretation and post processing in cardiovascular magnetic resonance: Society for Cardiovascular Magnetic Resonance (SCMR) Board of Trustees Task Force on Standardized Post ProcessingJournal of Cardiovascular Magnetic Resonance, 2013
- 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the American Association for Thoracic Surgery, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic SurgeonsJournal of the American College of Cardiology, 2011
- Contemporary approaches to the identification of athletes at risk for sudden cardiac deathCurrent Opinion in Cardiology, 2008
- Usefulness of N-Terminal Pro-B-Type Natriuretic Peptide to Predict Clinical Course in Patients With Hypertrophic CardiomyopathyThe American Journal of Cardiology, 2006
- Essential biochemistry and physiology of (NT‐pro)BNPEuropean Journal of Heart Failure, 2004
- Hypertrophic CardiomyopathyJAMA, 2002
- Efficacy of Implantable Cardioverter–Defibrillators for the Prevention of Sudden Death in Patients with Hypertrophic CardiomyopathyThe New England Journal of Medicine, 2000