Confounding effect of blood volume and body mass index on blood neurofilament light chain levels
Top Cited Papers
Open Access
- 1 January 2020
- journal article
- research article
- Published by Wiley in Annals of Clinical and Translational Neurology
- Vol. 7 (1), 139-143
- https://doi.org/10.1002/acn3.50972
Abstract
Blood Neurofilament light chain (NfL) has been suggested as a promising biomarker in several neurological conditions. Since blood NfL is the consequence of leaked NfL from the cerebrospinal fluid, differences in individuals’ Body Mass Index (BMI) or blood volume (BV) might affect its correlation to other biomarkers and disease outcomes. Here, we investigated the correlation between plasma NfL, BMI, and BV in 662 controls and 2,586 multiple sclerosis cases. We found a significant negative correlation between plasma NfL, BMI/BV in both groups. Our results highlight the potential confounding effect of BMI/BV on associations between blood NfL and disease outcomes.Funding Information
- Novartis
- Biogen
- Vetenskapsrådet
- AFA Försäkring
- Genzyme
- Hjärnfonden
- Korea National University of Transportation
- Sanofi
This publication has 7 references indexed in Scilit:
- Neurofilament light chain as a biomarker in neurological disordersJournal of Neurology, Neurosurgery & Psychiatry, 2019
- Neurofilaments as biomarkers in neurological disordersNature Reviews Neurology, 2018
- Monitoring disease activity in multiple sclerosis using serum neurofilament light proteinNeurology, 2017
- Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcomeJournal of Neurology, Neurosurgery & Psychiatry, 2014
- Smoking and multiple sclerosis susceptibilityEuropean Journal of Epidemiology, 2013
- A Swedish national post-marketing surveillance study of natalizumab treatment in multiple sclerosisMultiple Sclerosis Journal, 2011
- Prediction of blood volume in normal human adults.1962