Rapid Changes in Serum Testosterone in Men With Newly Diagnosed Type 2 Diabetes With Intensive Insulin and Metformin
- 3 February 2021
- journal article
- research article
- Published by American Diabetes Association in Diabetes Care
- Vol. 44 (4), 1059-1061
- https://doi.org/10.2337/dc20-1558
Abstract
OBJECTIVE To investigate the effect of metformin on testosterone levels in men with type 2 diabetes mellitus (T2DM). RESEARCH DESIGN AND METHODS Seventy men with newly diagnosed drug-naive T2DM and HbA1c >9.0% (75 mmol/mol) were treated with intensive insulin pump therapy for 5 days to achieve glucose normalization. They were randomized to control (continued on intensive insulin only) and metformin (plus metformin) groups (1:1) for 1 month. Testosterone was measured at baseline, randomization, and after 1-month treatment. RESULTS Total, free, and bioavailable testosterone increased significantly within 5 days (all P < 0.001). After 1 month, compared with the control group, the metformin group had lower total (12.7 vs. 15.3 nmol/L), free (0.20 vs. 0.24 nmol/L), and bioavailable (4.56 vs. 5.31 nmol/L) testosterone (all P < 0.05). CONCLUSIONS In men with T2DM, 1-month oral metformin may decrease serum testosterone levels independent of blood glucose control. The effects of long-term metformin on testosterone in men need further study.Keywords
Other Versions
Funding Information
- National Key R&D Program of China (2018YFC1314103)
- National Natural Science Foundation of China (81870563)
- Nanjing Municipal Science and Technology Project (201803011)
This publication has 30 references indexed in Scilit:
- Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 DiabetesDiabetes Care, 2015
- Randomized Controlled Trial of Intensive Versus Conservative Glucose Control in Patients Undergoing Coronary Artery Bypass Graft Surgery: GLUCO-CABG TrialDiabetes Care, 2015
- Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetesActa Endocrinologica, 2013
- Metformin Use and All-Cause and Prostate Cancer–Specific Mortality Among Men With DiabetesJournal of Clinical Oncology, 2013
- Low Testosterone in Men with Type 2 Diabetes: Significance and TreatmentJournal of Clinical Endocrinology & Metabolism, 2011
- Metformin improves semen characteristics of oligo-terato-asthenozoospermic men with metabolic syndromeFertility and Sterility, 2011
- A comparison study of continuous insulin infusion protocols in the medical intensive care unit: Computer‐guided vs. standard column‐based algorithmsJournal of Hospital Medicine, 2010
- 10-Year Follow-up of Intensive Glucose Control in Type 2 DiabetesThe New England Journal of Medicine, 2008
- Calculation of Bioavailable and Free Testosterone in Men: A Comparison of 5 Published AlgorithmsClinical Chemistry, 2006
- Clinical, Metabolic and Endocrine Parameters in Response to Metformin in Obese Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind and Placebo-Controlled TrialHormone and Metabolic Research, 2003