Transcatheter arterial chemoembolization followed by surgical resection for hepatocellular carcinoma: a focus on its controversies and screening of patients most likely to benefit
Open Access
- 28 September 2021
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Chinese Medical Journal
- Vol. 134 (19), 2275-2286
- https://doi.org/10.1097/cm9.0000000000001767
Abstract
Surgical resection (SR) is recommended as a radical procedure in the treatment of hepatocellular carcinoma (HCC). However, postoperative recurrence negatively affects the long-term efficacy of SR, and preoperative adjuvant therapy has therefore become a research hotspot. Some clinicians adopt transcatheter arterial chemoembolization (TACE) as a preoperative adjuvant therapy in patients undergoing SR to increase the resection rate, reduce tumor recurrence, and improve the prognosis. However, the findings of the most relevant studies remain controversial. Some studies have confirmed that preoperative TACE cannot improve the long-term survival rate of patients with HCC and might even negatively affect the resection rate. Which factors influence the efficacy of preoperative TACE combined with SR is a topic worthy of investigation. In this review, existing clinical studies were analyzed with a particular focus on several topics: screening of the subgroups of patients most likely to benefit from preoperative TACE, exploration of the optimal treatment regimen of preoperative TACE, and determination of the extent of tumor necrosis as the deciding prognostic factor.Keywords
This publication has 115 references indexed in Scilit:
- Meta-analysis: preoperative transcatheter arterial chemoembolization does not improve prognosis of patients with resectable hepatocellular carcinomaBMC Gastroenterology, 2013
- Hepatitis B virus reactivation in hepatocellular carcinoma patients undergoing transcatheter arterial chemoembolization therapyAsia-Pacific Journal of Clinical Oncology, 2012
- Radiological response predicts survival following transarterial chemoembolisation in patients with unresectable hepatocellular carcinomaAlimentary Pharmacology & Therapeutics, 2012
- A Prospective Randomized Controlled Trial of Preoperative Whole-Liver Chemolipiodolization for Hepatocellular CarcinomaDigestive Diseases and Sciences, 2012
- Long-term outcome of preoperative transarterial chemoembolization and hepatic resection in patients with hepatocellular carcinomaThe Korean Journal of Hepatology, 2010
- A randomized controlled trial of hepatectomy with adjuvant transcatheter arterial chemoembolization versus hepatectomy alone for Stage III A hepatocellular carcinomaZeitschrift für Krebsforschung und Klinische Onkologie, 2009
- The effect of preoperative transarterial chemoembolization of resectable hepatocellular carcinoma on clinical and economic outcomesJournal of Surgical Oncology, 2009
- Transcatheter Arterial Chemoembolization (TACE) in Hepatocellular Carcinoma (HCC): The Role of Angiogenesis and InvasivenessThe American Journal of Gastroenterology, 2008
- Preoperative transcatheter arterial chemoembolization reduces long-term survival rate after hepatic resection for resectable hepatocellular carcinomaEuropean Journal of Surgical Oncology, 2006
- Pulmonary metastasis of hepatocellular carcinoma associated with transarterial chemoembolizationJournal of Hepatology, 1995