Aging reduces cerebral blood flow regulation following an acute hypertensive stimulus
- 1 May 2020
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 128 (5), 1186-1195
- https://doi.org/10.1152/japplphysiol.00137.2019
Abstract
Reductions in cerebral blood flow and increases in flow pulsatility with aging are associated to cerebrovascular disease; however, little is known about how an acute hypertensive stimulus effects cerebral blood flow regulation in an aged population. Following the hypertensive stimulus, older adults elicit an attenuated increase in cerebral blood velocity and greater transmission of pulsatile velocity to the brain compared with young adults, demonstrating reduced cerebral blood flow regulation to elevated blood pressure responses with aging.Keywords
This publication has 59 references indexed in Scilit:
- Effects of Resistive Exercise on Cerebral Blood Flow Velocity and Pulsatility Index of Healthy PeopleJournal of Physical Therapy Science, 2012
- Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility – Reykjavik StudyBrain, 2011
- Cerebrovascular hemodynamics, gait, and falls in an elderly populationNeurology, 2010
- Arterial Stiffness and Cardiovascular EventsCirculation, 2010
- Interaction between the ventilatory and cerebrovascular responses to hypo‐ and hypercapnia at rest and during exerciseJournal Of Physiology-London, 2008
- Elevation in cerebral blood flow velocity with aerobic fitness throughout healthy human ageingJournal Of Physiology-London, 2008
- Arterial stiffness as an independent predictor of longitudinal changes in cognitive function in the older individualJournal of Hypertension, 2007
- Cerebral autoregulation is temporarily disturbed in the early recovery phase after dynamic resistance exerciseClinical Autonomic Research, 2005
- Aortic Stiffness Is an Independent Predictor of Fatal Stroke in Essential HypertensionStroke, 2003
- Phase Relationship Between Cerebral Blood Flow Velocity and Blood PressureStroke, 1995