Cotinine levels influence the risk of rupture of brain aneurysms
Open Access
- 3 August 2022
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 146 (5), 562-567
- https://doi.org/10.1111/ane.13679
Abstract
Cotinine, the primary metabolite of nicotine, is currently regarded as the best biomarker of tobacco smoke exposure. We aim to assess whether cotinine levels are associated with (1) intracranial aneurysm and (2) intracranial aneurysm rupture. Methods: We performed a single-center case-control study. Cases were consecutive patients admitted with diagnosis of brain aneurysm (ruptured or unruptured). We randomly selected controls without intracranial aneurysm from the same source population that produced the cases. Smoking data were collected by questionnaire, and serum levels of cotinine were used as an objective measure of nicotine exposure. Logistic regression models were used to assess the relationship between cotinine levels and aneurysm rupture. Results: We included 86 patients with intracranial aneurysm and 96 controls. Smoking status (p < .001), cotinine levels (p = .009), and female sex (p = .006) were associated with diagnosis of intracranial aneurysm. In the multivariate analysis, controlling for sex, smoker status and age, levels of cotinine were independently associated with aneurysm rupture (OR 1.53, 95% CI 1.10-2.13, p = .012). Conclusions: Our results suggest that high cotinine levels in smokers with brain aneurysm are significantly associated with high rupture risk, independently of smoker status, age, and sex.Keywords
This publication has 28 references indexed in Scilit:
- European Stroke Organization Guidelines for the Management of Intracranial Aneurysms and Subarachnoid HaemorrhageCerebrovascular Diseases, 2013
- Using NicAlert strips to verify smoking status among pregnant cigarette smokersDrug and Alcohol Dependence, 2011
- Smoking and family history and risk of aneurysmal subarachnoid hemorrhageNeurology, 2009
- Diagnostic accuracy of NicAlert cotinine test strips in saliva for verifying smoking statusNicotine & Tobacco Research, 2008
- Mortality and life expectancy in relation to long-term cigarette, cigar and pipe smoking: The Zutphen StudyTobacco Control, 2007
- Smoking and non-smoking tobacco as risk factors in subarachnoid haemorrhageActa Neurologica Scandinavica, 2006
- The Relationships of Gender, Cigarette Smoking, and Hypertension with the Risk of Aneurysmal Subarachnoid Hemorrhage: A Case–Control Study in Nagoya, JapanAnnals of Epidemiology, 2005
- Measurement of self reported active exposure to cigarette smokeJournal of Epidemiology and Community Health, 2001
- Factors Affecting Formation and Growth of Intracranial AneurysmsStroke, 2001
- Absorption of Nicotine in Cigarette and Cigar Smoke through the Oral MucosaNature, 1970