Uncertain Identity of Doxorubicin-Resistant MCF-7 Cell Lines Expressing Mutated p53

Abstract

The doxorubicin (ADR)-selected human breast cancer cell line (MCF-7/ADR-RES) has been a useful model for a multidrug-resistant subline in cancer research. However, a recent letter to the Journal has alerted the scientific community about the finding that MCF-7/ADR-RES is not a MCF-7-derived cell line. This report led to a change of nomenclature from MCF-7/ADR-RES to NCI/ADR-RES (1).