Strong Negative Association of non-HDL Cholesterol Goal Achievement With Incident CKD Among Adults With Diabetes
Open Access
- 21 December 2022
- journal article
- research article
- Published by The Endocrine Society in Journal of the Endocrine Society
- Vol. 7 (3), bvac193
- https://doi.org/10.1210/jendso/bvac193
Abstract
Aims We evaluated the effect of the achievement of HbA1c, systolic blood pressure (SBP) and LDL (LDLc) or non-HDL cholesterol (non-HDLc) goals (ABC goals) on the development of chronic kidney disease (iCKD) among patients with diabetes. Methods In a nationwide registry of all individuals with diagnosed diabetes assisted by the health system in Colombia, we analyzed the association between baseline or sustained goal achievement and development of iCKD over a four-year follow-up. Incident CKD was defined as a new occurrence of an estimated glomerular filtration rate 2, hemodialysis, peritoneal dialysis, or kidney transplant. Results The study included 998 790 adults with diabetes (56% female, mean age 59). There were 125 626 cases of incident CKD. After adjustment for multiple confounders, a baseline SBP < 130 mmHg (OR 0.79 [0.78-0.80]) and a baseline HbA1c < 7.0% (OR 0.86 [0.85-0.87]) were negatively associated with iCKD. Sustained achievement showed stronger negative associations with iCKD than just baseline achievement. Considering each goal separately, sustained non-HDLc p for interaction 0.002). Conclusions At a country level, sustained achievement of ABC goals and most especially non-HDLc were associated with substantial reductions in iCKD.This publication has 39 references indexed in Scilit:
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