Game theoretical mapping of white matter contributions to visuospatial attention in stroke patients with hemineglect
Open Access
- 3 April 2020
- journal article
- research article
- Published by Wiley in Human Brain Mapping
- Vol. 41 (11), 2926-2950
- https://doi.org/10.1002/hbm.24987
Abstract
White matter bundles linking gray matter nodes are key anatomical players to fully characterize associations between brain systems and cognitive functions. Here we used a multivariate lesion inference approach grounded in coalitional game theory (multiperturbation Shapley value analysis, MSA) to infer causal contributions of white matter bundles to visuospatial orienting of attention. Our work is based on the characterization of the lesion patterns of 25 right hemisphere stroke patients and the causal analysis of their impact on three neuropsychological tasks: line bisection, letter cancellation, and bells cancellation. We report that, out of the 11 white matter bundles included in our MSA coalitions, the optic radiations, the inferior fronto‐occipital fasciculus and the anterior cingulum were the only tracts to display task‐invariant contributions (positive, positive, and negative, respectively) to the tasks. We also report task‐dependent influences for the branches of the superior longitudinal fasciculus and the posterior cingulum. By extending prior findings to white matter tracts linking key gray matter nodes, we further characterize from a network perspective the anatomical basis of visual and attentional orienting processes. The knowledge about interactions patterns mediated by white matter tracts linking cortical nodes of attention orienting networks, consolidated by further studies, may help develop and customize brain stimulation approaches for the rehabilitation of visuospatial neglect.Keywords
Funding Information
- Sixth Framework Programme
This publication has 154 references indexed in Scilit:
- Manipulation of Pre-Target Activity on the Right Frontal Eye Field Enhances Conscious Visual Perception in HumansPLOS ONE, 2012
- Cytoarchitecture and cortical connections of the anterior cingulate and adjacent somatomotor fields in the rhesus monkeyBrain Research Bulletin, 2012
- Cortical Network for Gaze Control in Humans Revealed Using Multimodal MRICerebral Cortex, 2011
- The hodology of hallucinationsCortex, 2008
- The Reorienting System of the Human Brain: From Environment to Theory of MindNeuron, 2008
- Brain networks of spatial awareness: evidence from diffusion tensor imaging tractographyJournal of Neurology, Neurosurgery & Psychiatry, 2008
- Enantiomorphic normalization of focally lesioned brainsNeuroImage, 2008
- Visual neglect after right posterior cerebral artery infarctionJournal of Neurology, Neurosurgery & Psychiatry, 2006
- Diffusion tensor imaging: Concepts and applicationsJournal of Magnetic Resonance Imaging, 2001
- Projections to the frontal cortex from the posterior parietal region in the rhesus monkeyJournal of Comparative Neurology, 1984