An investigation about chronic prostatitis in ankylosing spondylitis
Open Access
- 4 May 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Advances in Rheumatology
- Vol. 61 (1), 1-5
- https://doi.org/10.1186/s42358-021-00180-w
Abstract
Chronic prostatitis has been a common disease reported with high frequency in ankylosing spondylitis (AS) even from decades ago. Infectious (Chlamydia trachomatis) or non-infectious (uric acid) prostatitis can hypothetically trigger vertebral inflammation in AS. This study aimed to assess the features of chronic prostatitis in patients with AS compared to healthy controls. A cross-sectional study including male patients with AS and healthy controls who agreed to undergo a prostate examination was conducted. Structured clinical interviews, prostate physical examinations, and cytological, biochemical, and microbiological tests on urinary samples collected before and after standardized prostatic massage (pre- and post-massage test) were performed. Ninety participants (45 AS patients, mean age: 52.5 ± 10.0 years, with longstanding disease, 12.4 ± 6.9 years, and 45 controls, mean age: 52.8 ± 12.1 years) were included. National Institutes of Health - Chronic Prostatitis Symptom Index (NIH-CPSI) scores were similar in the AS and control groups (4.0 [1.0–12.0] vs. 5.0 [1.0–8.5], p = 0.994). The frequencies of symptoms of chronic prostatitis (NIH-CPSI Pain Domain ≥4) were also similar in both groups (23.3% vs. 22.7%, p = 0.953). Results of polymerase chain reaction tests for Chlamydia trachomatis were negative in all tested urinary samples, and uric acid concentrations and leukocyte counts were similar in all pre- and post-massage urinary samples. In this study, chronic prostatitis occurred in male patients with AS, but its frequency and characteristics did not differ from those found in the healthy male population of similar age.Keywords
This publication has 16 references indexed in Scilit:
- Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off values for disease activity states and improvement scoresAnnals Of The Rheumatic Diseases, 2010
- Microbial antigens mediate HLA-B27 diseases via TLRsJournal of Autoimmunity, 2009
- Epidemiology of prostatitisInternational Journal of Antimicrobial Agents, 2008
- Prevalence of prostatitis‐like symptoms in Japanese men: Population‐based study in a town in HokkaidoInternational Journal of Urology, 2006
- How Does the Pre-Massage and Post-Massage 2-Glass Test Compare to the Meares-Stamey 4-Glass Test in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome?Journal of Urology, 2006
- NIH Consensus Definition and Classification of ProstatitisJAMA, 1999
- Latin american study on patient acceptance of the international prostate symptom score (IPSS) in the evaluation of symptomatic benign prostatic hyperplasiaUrology, 1997
- Evaluation of Diagnostic Criteria for Ankylosing SpondylitisArthritis & Rheumatism, 1984
- Prostatitis and Ankylosing SpondylitisBMJ, 1958