In the course teaching innovation of forensic medicine specialty, this paper takes “crime scene” as the carrier, integrates the virtual-real TBL teaching method into the teaching design, and through the organic four combination of virtual and real, individual and team, online and offline, in-class and extracurricular, with the student-centered and teacher-guided, stimulates students’ learning initiative through the whole link. We enhance the innovation and advanced learning of professional courses and enhance the challenge of learning, so as to strengthen the practical skills and comprehensive quality of forensic medicine, help the cultivation of high-level profes-sional forensic medicine talents, and cultivate high-quality legal talents for the construction of the rule of law in China.