Patient's experiences of the barriers and facilitators to Methotrexate
- 8 July 2021
- journal article
- research article
- Published by Wiley in Musculoskeletal Care
- Vol. 20 (1), 158-166
- https://doi.org/10.1002/msc.1577
Abstract
Objective To investigate the barriers and facilitators of adherence to methotrexate (MTX) in people with rheumatic diseases and to explore the experience of shared decision-making. Methods A qualitative study was carried out. People diagnosed with inflammatory arthritides or systemic autoimmune diseases and who were treated with MTX were invited to participate in focus groups. The discourse was coded and synthesised with a content analysis approach. Results The groups included 12 representative patients (rheumatoid arthritis, spondylarthritis, and systemic lupus erythematosus, taking either oral or subcutaneous MTX). Four main themes were identified: (1) drug-related aspects (package insert, adverse events, administration, and difficulties with treatment); (2) patient-physician relationship; (3) social environment (lack of visibility of rheumatic diseases and the support of patient associations); and (4) medication and medical care practicalities (information, reliable sources, and expanding knowledge in other health areas). Conclusions Aspects identified might help improve adherence, including quality information, especially on adverse events, the role of the setting, and shared decision-making.This publication has 32 references indexed in Scilit:
- Evaluating drug-free remission with abatacept in early rheumatoid arthritis: results from the phase 3b, multicentre, randomised, active-controlled AVERT study of 24 months, with a 12-month, double-blind treatment periodAnnals Of The Rheumatic Diseases, 2014
- Patient participation in decisions about disease modifying anti-rheumatic drugs: a cross-sectional surveyBMC Musculoskeletal Disorders, 2014
- EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 updateAnnals Of The Rheumatic Diseases, 2013
- Advancing the Responsible Use of Medicines: Applying Levers for ChangeSSRN Electronic Journal, 2012
- Assessment of the general public's knowledge about rheumatic diseases: evidence from a Portuguese population-based surveyBMC Musculoskeletal Disorders, 2010
- Dual equipoise shared decision making: definitions for decision and behaviour support interventionsImplementation Science, 2009
- Patient Participation in Medical ConsultationsMedical Care, 2005
- Participatory patient–physician communication and morbidity in patients with systemic lupus erythematosusArthritis Care & Research, 2003
- The general public's knowledge and perceptions about rheumatic diseasesAnnals Of The Rheumatic Diseases, 2000
- Patient participation - a review of the literatureJournal of Clinical Nursing, 1998