Abstract
We conducted a study including patients with tension type headache (TTH) (n = 60) at the age of 37.2 ± 10.2. The criteria for the International Headache Classification, third edition (beta version) were used. The following outcome measures were compared: EEG, visual analog scale (VAS), hospital anxiety and depression scale (HADS), Beck Depression Inventory (BDI), pulse variation measurement, Wein Scale. 60 patients presenting with TTH were randomly assigned to phenibut (500 mg/day) or selective serotonin reuptake inhibitors (SSRI) for 4 weeks. The findings indicate the potential benefit of phenibut as effective and safe symptomatic therapy in diverse forms of tension type headache.

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