Nipple Sparing Mastectomy as a Risk-Reducing Procedure for BRCA-Mutated Patients
Open Access
- 10 February 2021
- Vol. 12 (2), 253
- https://doi.org/10.3390/genes12020253
Abstract
Growing numbers of asymptomatic women who become aware of carrying a breast cancer gene mutation (BRCA) mutation are choosing to undergo risk-reducing bilateral mastectomies with immediate breast reconstruction. We reviewed the literature with the aim of assessing the oncological safety of nipple-sparing mastectomy (NSM) as a risk-reduction procedure in BRCA-mutated patients. Nine studies reporting on the incidence of primary breast cancer post NSM in asymptomatic BRCA mutated patients undergoing risk-reducing bilateral procedures met the inclusion criteria. NSM appears to be a safe option for BRCA mutation carriers from an oncological point of view, with low reported rates of new breast cancers, low rates of postoperative complications, and high levels of satisfaction and postoperative quality of life. However, larger multi-institutional studies with longer follow-up are needed to establish this procedure as the best surgical option in this setting.This publication has 28 references indexed in Scilit:
- Risk-reducing surgery increases survival in BRCA1/2 mutation carriers unaffected at time of family referralBreast Cancer Research and Treatment, 2013
- Total Skin-Sparing Mastectomy in BRCA Mutation CarriersAnnals of Surgical Oncology, 2013
- Prophylactic and Therapeutic Mastectomy in BRCA Mutation Carriers: Can the Nipple Be Preserved?Annals of Surgical Oncology, 2011
- Nipple-Sparing Mastectomy for Breast Cancer and Risk-Reducing Surgery: The Memorial Sloan-Kettering Cancer Center ExperienceAnnals of Surgical Oncology, 2011
- Areola and Nipple-Areola-Sparing Mastectomy for Breast Cancer Treatment and Risk Reduction: Report of an Initial Experience in a Community Hospital SettingAnnals of Surgical Oncology, 2010
- Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers With Cancer Risk and MortalityJAMA, 2010
- Nipple-sparing mastectomyBritish Journal of Surgery, 2010
- Meta-Analysis of BRCA1 and BRCA2 PenetranceJournal of Clinical Oncology, 2007
- Breast Cancer after Prophylactic Bilateral Mastectomy in Women with aBRCA1orBRCA2MutationThe New England Journal of Medicine, 2001