Brain resilience across the general cognitive ability distribution: Evidence from structural connectivity
- 20 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Brain Structure and Function
- Vol. 226 (3), 845-859
- https://doi.org/10.1007/s00429-020-02213-4
Abstract
Resting state functional connectivity research has shown that general cognitive ability (GCA) is associated with brain resilience to targeted and random attacks (TAs and RAs). However, it remains to be seen if the finding generalizes to structural connectivity. Furthermore, individuals showing performance levels at the very high area of the GCA distribution have not yet been analyzed in this regard. Here we study the relation between TAs and RAs to structural brain networks and GCA. Structural and diffusion-weighted MRI brain images were collected from 189 participants: 60 high cognitive ability (HCA) and 129 average cognitive ability (ACA) individuals. All participants completed a standardized fluid reasoning ability test and the results revealed an average HCA-ACA difference equivalent to 33 IQ points. Automated parcellation of cortical and subcortical nodes was combined with tractography to achieve an 82 × 82 connectivity matrix for each subject. Graph metrics were derived from the structural connectivity matrices. A simulation approach was used to evaluate the effects of recursively removing nodes according to their network centrality (TAs) versus eliminating nodes at random (RAs). HCA individuals showed greater network integrity at baseline and prior to network collapse than ACA individuals. These effects were more evident for TAs than RAs. The networks of HCA individuals were less degraded by the removal of nodes corresponding to more complex information processing stages of the PFIT network, and from removing nodes with larger empirically observed centrality values. Analyzed network features suggest quantitative instead of qualitative differences at different levels of the cognitive ability distribution.Keywords
Funding Information
- Ministerio de Economía, Industria y Competitividad, Gobierno de España (PSI2017-82218-P)
This publication has 53 references indexed in Scilit:
- Childhood cognitive ability accounts for associations between cognitive ability and brain cortical thickness in old ageMolecular Psychiatry, 2013
- Architecture of fluid intelligence and working memory revealed by lesion mappingBrain Structure and Function, 2013
- An integrative architecture for general intelligence and executive function revealed by lesion mappingBrain, 2012
- TDCS guided using fMRI significantly accelerates learning to identify concealed objectsNeuroImage, 2012
- Cortical thickness correlates of specific cognitive performance accounted for by the general factor of intelligence in healthy children aged 6 to 18NeuroImage, 2011
- Modulating Neuronal Activity Produces Specific and Long-Lasting Changes in Numerical CompetenceCurrent Biology, 2010
- Intelligence and Personality as Predictors of Illness and DeathPsychological Science in the Public Interest, 2010
- Distributed neural system for general intelligence revealed by lesion mappingProceedings of the National Academy of Sciences of the United States of America, 2010
- Modeling the Impact of Lesions in the Human BrainPLoS Computational Biology, 2009
- Lesion Mapping of Cognitive Abilities Linked to IntelligenceNeuron, 2009