Associations between Circulating Lipids and Fat-Soluble Vitamins and Carotenoids in Healthy Overweight and Obese Men
Open Access
- 11 June 2020
- journal article
- research article
- Published by Elsevier BV in Current Developments in Nutrition
- Vol. 4 (6), nzaa089
- https://doi.org/10.1093/cdn/nzaa089
Abstract
Inconsistent associations between lipids and circulating markers of fat-soluble vitamin and carotenoid status have been reported. The aim of this hypothesis-generating study was to examine the contribution of the LC-MS-based lipidome, characterized by lipid class, carbon count, and the number of unsaturated bonds, to the interindividual variability in circulating concentrations of retinol, carotenoids, 25-hydroxyvitamin D3, α-tocopherol, γ-tocopherol, and phylloquinone in 35 overweight and obese, but healthy men. A sparse partial least-squares method was used to accomplish this aim. Highly abundant phospholipids and triglycerides (TGs) contributed to the interindividual variability in phylloquinone, α-tocopherol, and γ-tocopherol. Interindividual variability in lycopene concentrations was driven by concentrations of low-abundant TG. 25-Hydroxyvitamin D3, retinol, and the other carotenoids were not influenced by lipids. Except for lycopene, evaluation of lipids beyond class does not appear to further explain the interindividual variability in circulating concentrations of fat-soluble vitamins and carotenoids.Keywords
Funding Information
- USDA Agricultural Research Service (581950-7-707)
This publication has 29 references indexed in Scilit:
- Assessing vitamin status in large population surveys by measuring biomarkers and dietary intake – two case studies: folate and vitamin DFood & Nutrition Research, 2012
- Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problemsBMC Bioinformatics, 2011
- Lipidomics reveals a remarkable diversity of lipids in human plasmaJournal of Lipid Research, 2010
- An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approachThe American Journal of Clinical Nutrition, 2010
- Reproductive performance and bone status markers of gilts and lactating sows supplemented with two different forms of vitamin D1Journal of Animal Science, 2010
- Analytical Error Reduction Using Single Point Calibration for Accurate and Precise Metabolomic PhenotypingJournal of Proteome Research, 2009
- The external quality assurance of phylloquinone (vitamin K1) analysis in human serumBiomedical Chromatography, 2009
- Metabolic Profiling of the Response to an Oral Glucose Tolerance Test Detects Subtle Metabolic ChangesPLOS ONE, 2009
- Vitamin E and K interactions - a 50-year-old problemNutrition Reviews, 2008
- Human plasma transport of vitamin D after its endogenous synthesis.JCI Insight, 1993