Photorelease of a metal-binding pharmacophore from a Ru(ii) polypyridine complex

Abstract

The adoption of compounds that target metalloenzymes comprises a relatively low (in vitro assay, the conjugate generated inhibition upon light exposure at 450 nm, demonstrating the ability to liberate the metalloenzyme inhibitor. The presented inhibitor–Ru(II) polypyridine conjugate is an example of computationally-guided drug design for light-activated drug release and may help reveal new avenues for the prodrugging of metalloenzyme inhibitors.