Improvement in A1c Levels in Early Adulthood in the T1D Exchange: Impact of Racial, Socioeconomic, and Clinical Factors
- 10 February 2021
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 106 (5), 1294-1302
- https://doi.org/10.1210/clinem/dgab077
Abstract
Context Glycemic control in adolescents with type 1 diabetes is poor; yet, it typically improves during early adulthood. Factors related to improvement of glycemic control are unclear. Objective This work examines how demographic and clinical variables may affect trajectories of glycemic control over time. Methods This retrospective, observational study comprised 1775 participants ages 18 to 30 years at enrollment in the T1D Exchange clinic registry. Latent class trajectory modeling was used to determine subgroups following a similar glycated hemoglobin A1c (HbA1c) trajectory over time. Results Five distinct trajectories of HbA1c classes were identified: “low-decline” and “moderate-decline” groups had low or moderate HbA1c with a gradual decline, the “high-stable” group had high HbA1c and remained stable, and the “very high-rapid decline” and “very high-slow decline” groups had very high HbA1c with rapid or gradual decline. Compared with the “high-stable” group, the “low-decline” and “moderate-decline” groups were more likely to be male (P = .009), White non-Hispanic (P = .02), nonsmokers (P < .001), check self-monitoring blood glucose (SMBG) more frequently (P < .001), and have higher education (P < .001), lower body mass index (P = .02), and lower daily insulin dose (P < .001). Compared with the “very high-rapid decline” and “very high-slow decline” groups, the “low-decline” and “moderate-decline” groups were more likely to be male (P = .02), have higher education (P < .001), use insulin pumps (P = .01), be nonsmokers (P < .001), and have a higher number of SMBG checks per day at enrollment (P < .001). Conclusion We determined 5 distinct patterns of glycemic control from early adulthood into adulthood. Further evaluation into the modifiable factors associated with a declining HbA1c trajectory would aid in the development of targeted interventions.Keywords
Funding Information
- Leona M. and Harry B. Helmsley Charitable Trust
This publication has 19 references indexed in Scilit:
- Five heterogeneous HbA1c trajectories from childhood to adulthood in youth with type 1 diabetes from three different continents: A group‐based modeling approachPediatric Diabetes, 2019
- State of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016–2018Diabetes Technology & Therapeutics, 2019
- Association of Race and Ethnicity With Glycemic Control and Hemoglobin A1c Levels in Youth With Type 1 DiabetesJAMA Network Open, 2018
- Exploring Variation in Glycemic Control Across and Within Eight High-Income Countries: A Cross-sectional Analysis of 64,666 Children and Adolescents With Type 1 DiabetesDiabetes Care, 2018
- Longitudinal Trajectories of Metabolic Control From Childhood to Young Adulthood in Type 1 Diabetes From a Large German/Austrian Registry: A Group-Based Modeling ApproachDiabetes Care, 2016
- Glycemic control and complications in patients with type 1 diabetes - a registry-based longitudinal study of adolescents and young adultsPediatric Diabetes, 2016
- Hemoglobin A1c (HbA1c) changes over time among adolescent and young adult participants in the T1D exchange clinic registryPediatric Diabetes, 2015
- Glycaemic control of Type 1 diabetes in clinical practice early in the 21st century: an international comparisonDiabetic Medicine, 2014
- The T1D Exchange Clinic RegistryJournal of Clinical Endocrinology & Metabolism, 2012
- A SAS Procedure Based on Mixture Models for Estimating Developmental TrajectoriesSociological Methods & Research, 2001