Introduction: the conditions of the COVID-19 pandemic promote mental health risks. Objective: the goal of the study was to assess the risk of developing mental health conditions as a result of COVID-19 situations: containment, symptoms or COVID-19 suspected, death of near people, use of alcohol, and violence. Method: it participated 8,348 Mexican, with a mean of 25 years old (SD =11.24), 50% single (4,133), 69% women (5,720), 47% in quarantine (3,948), 50% partially in quarantine (4,193), and 3% that they were not in quarantine (207). The kind proposed was a predictive correlational study using the WebApp application of the Questionnaire of Mental Health Screening in COVID-19 (Alpha= 0.96; 64 of explained variance) programed by Linux®, PHP ®, HTML®, CSS ®, and JavaScript®). Latent variables derivate of 124 iterations with 103 parameters (t[496] = 201,464, p=.000), a CFI = 0.921, a TLI = 0.908, a RMSEA = 0.067 (0.066 – 0.068), and a SRMR = 0.051. Results: results showed that avoidance predicted acute stress, this predicted anxiety related to health; anxiety related to health predicted generalized anxiety/sadness and somatization; and generalized anxiety/sadness predicted, disengagement/anger in people. Discussion and conclusions: containment, symptoms, or suspected COVID-19, explosive use of alcohol or reporting of emotional or physical violence, were associated with the risk of mental health conditions. Next studies should assess the impact of distance psychological interventions over the risk of developing acute and posttraumatic stress.