Economic evaluation of a multimodal intervention in pre-frail and frail older people with diabetes mellitus: the MID-FRAIL project
- 2 January 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in Expert Review of Pharmacoeconomics & Outcomes Research
- Vol. 21 (1), 111-118
- https://doi.org/10.1080/14737167.2020.1766970
Abstract
Background The aim of this study was to estimate the incremental cost-utility ratio (ICUR) of a multi-modal intervention in frail and pre-frail subjects aged >= 70 years with type-2 diabetes versus usual care group focused on quality adjusted life years (QALYs) in different European countries. Methods The MID-FRAIL study was a cluster randomized multicentre trial conducted in seven European countries. A cost-utility analysis was carried out based on this study, conducted from the perspective of the health care system with a time horizon of one year. Univariate and probabilistic analysis were carried out to test the robustness of the results. Results The cost estimation showed the offsetting health effect of the intervention program on total health care costs. The mean annual health care costs were 25% higher among patients in usual care. The mean incremental QALY gained per patient by the intervention group were 0.053 QALY compared with usual care practice. Conclusions The MID-FRAIL intervention program showed to be the dominant option in comparison with usual care practice. It saved costs to the health care system and achieved worthwhile health gains. This finding should encourage its implementation, at least, in the trial participant countries.Funding Information
- The European Commission (.)
This publication has 63 references indexed in Scilit:
- Construction of the first genetic linkage map of Japanese gentian (Gentianaceae)BMC Genomics, 2012
- Effects of a physical training and nutritional intervention program in frail elderly people regarding habitual physical activity level and activities of daily living—A randomized controlled pilot studyArchives of Gerontology and Geriatrics, 2010
- Moving against frailty: does physical activity matter?Biogerontology, 2010
- Comparison of the prognostic importance of diagnosed diabetes, co‐morbidity and frailty in older peopleDiabetic Medicine, 2010
- Health-related quality of life in diabetes: The associations of complications with EQ-5D scoresHealth and Quality of Life Outcomes, 2010
- Physical Activity as a Preventative Factor for Frailty: The Health, Aging, and Body Composition StudyThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2009
- Multidimensional Geriatric Assessment: Back to the Future Cost-Effectiveness of a Multidisciplinary Intervention Model for Community-Dwelling Frail Older PeopleThe Journals of Gerontology, Series A: Biological Sciences and Medical Sciences, 2008
- Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trialThe Lancet, 2007
- Impact of Recent Increase in Incidence on Future Diabetes BurdenDiabetes Care, 2006
- The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin-Dependent Diabetes MellitusThe New England Journal of Medicine, 1993