Changes of Branched-Chain Amino Acids and Ectopic Fat in Response to Weight-loss Diets: the POUNDS Lost Trial
- 1 October 2020
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 105 (10), e3747-e3756
- https://doi.org/10.1210/clinem/dgaa377
Abstract
Context Recent evidence has related circulating branch-chained amino acids (BCAAs) to ectopic fat distribution. Objective To investigate the associations of changes in plasma BCAAs induced by weight-loss diet interventions with hepatic fat and abdominal fat, and potential modification by different diets. Design, Setting, and Participants The current study included 184 participants from the 2-year Preventing Overweight and Using Novel Dietary Strategies (POUNDS Lost) trial with repeated measurements on plasma BCAAs, hepatic fat, and abdominal fat over 2 years. Main Outcome Measures Repeated measurements of hepatic fat, abdominal fat distribution, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and total adipose tissue (TAT). Results Over 2 years, a decrease in total plasma BCAAs was significantly associated with improvement in hepatic density (a marker for hepatic fat; p=0.02) and reductions in abdominal fat, including VAT, SAT, and TAT (all ppp-interaction=0.01). Participants with a larger decrease in total BCAAs showed a greater increase in hepatic density when consuming a high-protein diet, compared to those with a smaller decrease or increase in total BCAAs. Conclusions Our findings indicate that weight-loss diet induced-decrease in plasma BCAAs is associated with reductions of hepatic and abdominal fat. In addition, dietary protein intake may modify these associations.Keywords
Funding Information
- National Heart, Lung, and Blood Institute (HL071981, HL034594, HL126024)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK115679, DK091718, DK100383, DK078616)
- Boston Obesity Nutrition Research Center (DK46200)
- United States-Israel Binational Science Foundation (2011036)
- American Heart Association (0730094N)
- American Heart Association Predoctoral Student Fellowship Award (19PRE34380036)
This publication has 49 references indexed in Scilit:
- Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young AdultsDiabetes Care, 2013
- Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin ResistanceCell Metabolism, 2012
- Effects of 4 weight-loss diets differing in fat, protein, and carbohydrate on fat mass, lean mass, visceral adipose tissue, and hepatic fat: results from the POUNDS LOST trialThe American Journal of Clinical Nutrition, 2012
- Plasma metabolomic profile in nonalcoholic fatty liver diseaseMetabolism, 2011
- Metabolite profiles and the risk of developing diabetesNature Medicine, 2011
- Multiple imputation for missing data in epidemiological and clinical research: potential and pitfallsBMJ, 2009
- A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin ResistanceCell Metabolism, 2009
- Comparison of Weight-Loss Diets with Different Compositions of Fat, Protein, and CarbohydratesThe New England Journal of Medicine, 2009
- Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1Cell Metabolism, 2006
- Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivityNature, 2004