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Glial fibrillary acidic protein: a blood biomarker to differentiate neurodegenerative from psychiatric diseases

Published: 3 September 2021
 by  BMJ

Abstract: To facilitate biomarker-based detection of neurodegeneration in clinical practice, easy-to-use blood tests for first-line testing would be of great value. Such tests have been developed for Alzheimer’s disease pathology (plasma Aβ42/Aβ40 ratio and phosphorylated tau species), and for neurofilament light (NfL), a more general biomarker for neuroaxonal injury in both acute and chronic neurological conditions has been developed.1 In contrast, it has been difficult to identify biomarkers for psychiatric diseases—none exists to date and the most general biomarker NfL is negative.
Keywords: frontotemporal dementia / psychiatry / biochemistry

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