Assembling the prenylneoflavone system through a Pechmann condensation/Mitsunobu reaction/Claisen rearrangement/olefin cross-metathesis sequence
Open Access
- 1 April 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Monatshefte für Chemie / Chemical Monthly
- Vol. 151 (4), 605-610
- https://doi.org/10.1007/s00706-020-02584-8
Abstract
The multistep synthesis of a prenylneoflavone through a sequence of the Mitsunobu reaction/Claisen rearrangement/olefin cross-metathesis reaction has been accomplished in 5% yield over six steps starting from commercially available 3-methoxyacetophenone. The sequence is shown to be compatible with a Pechmann condensation which proved to be a robust and cost-effective method for the assembling of the alpha-pyrone core. The results open doors to a general approach to the prenylneoflavone system starting from phenol and acetophenone derivatives. [GRAPHICS] .This publication has 18 references indexed in Scilit:
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