Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension

Abstract

Vasopressors are commonly administered to patients in intensive care units (ICUs)^1,2 to avoid hypotension associated with myocardial injury, kidney injury, and death.^3,4 Vasopressors, however, may reduce blood flow in vasoconstricted vascular beds and are associated with effects on cardiac, metabolic, microbiome, and immune function.⁵ Balancing risks of hypotension with risks from vasopressors is, therefore, a challenge when managing patients in ICUs.