Association of Viral Load in SARS-CoV-2 Patients With Age and Gender
Open Access
- 27 January 2021
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Medicine
- Vol. 8, 608215
- https://doi.org/10.3389/fmed.2021.608215
Abstract
Background: The coronavirus disease 2019 (COVID-19), caused by the novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is a global public health emergency. Age and sex are two important factors associated with risks and outcomes of various diseases. COVID-19 morbidity also seems to be affected by patient age and sex. It has been found that older age groups have more severe COVID-19 symptoms and higher fatality rates while children tend to have lower prevalence and milder symptoms than adults. Methods: The study reviewed electronic medical records of COVID-19 patients from Madinah city, Saudi Arabia. The study included all cases who tested positive (n = 3,006) between March 20 and May 22, 2020. Data were obtained from the Health Electronic Surveillance Network (HESN) database. Results: Approximately 80% of the study sample were males and half were in the 30–40-year-old age group. The Ct value of the whole sample ranged from 15.08 to 35, with a mean of 27.44 (SD: 5.23; 95% C.I. = 27.25–27.66). The means of Ct values varied between age groups from 27.05 to 27.82. Analysis of the mean differences between age groups using one-way ANOVA indicated no statistically significant difference among the groups (F6,2999 = 1.63; p-value = 0.135). A comparison of mean Ct values of males (n = 2,422) and females (n = 584) revealed that males had a statistically significant higher mean Ct value (27.61 ± 5.20) than females (26.72 ± 5.31). The difference between the means of the two groups was −0.89 (95% C.I. = −1.36 to −0.42; t-test −3.71; df = 3,004; p-value < 0.001). Conclusion: The study found no statistically significant difference in viral loads between age groups. It showed that females had a higher SARS-CoV-2 viral load compared to males. The findings have implications for preventive strategies. Further studies are needed to correlate viral load with clinical symptoms and outcomes.Keywords
This publication has 32 references indexed in Scilit:
- Clinical characteristics of COVID-19 in Saudi Arabia: A national retrospective studyJournal of Infection and Public Health, 2020
- Sex differences in immune responses to SARS-CoV-2 that underlie disease outcomesmedRxiv : the preprint server for health sciences, 2020
- SARS-CoV-2 viral load assessment in respiratory samplesJournal of Clinical Virology, 2020
- Burden of Middle East respiratory syndrome coronavirus infection in Saudi ArabiaJournal of Infection and Public Health, 2020
- Gender Differences in Patients With COVID-19: Focus on Severity and MortalityFrontiers in Public Health, 2020
- Temporal dynamics in viral shedding and transmissibility of COVID-19Nature Medicine, 2020
- Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort studyThe Lancet Infectious Diseases, 2020
- Clinical features and dynamics of viral load in imported and non-imported patients with COVID-19International Journal of Infectious Diseases, 2020
- Estimating the Risk of Human Herpesvirus 6 and Cytomegalovirus Transmission to Ugandan Infants from Viral Shedding in Saliva by Household ContactsViruses, 2020
- Persistence of hepatitis B surface antibody and immune memory to hepatitis B vaccine among medical college students in MadinahAnnals of Saudi Medicine, 2018