Recurrent sterile abscesses in a case of X‐linked neutropenia
- 23 March 2020
- journal article
- research article
- Published by Wiley in Pediatric Dermatology
- Vol. 37 (4), 742-744
- https://doi.org/10.1111/pde.14146
Abstract
Cutaneous manifestations are common in monogenic immune disorders, including both infectious and non‐infectious etiologies. We report follow‐up of a case initially published in Pediatric Dermatology in 2001 of a 13‐year‐old boy with a history of inflammatory skin lesions and neutropenia who developed neutrophilic dermatoses precipitated by G‐CSF. Whole exome sequencing performed at 36 years of age revealed a gain‐of‐function mutation in the WAS gene, leading to a diagnosis of X‐linked neutropenia. This case report provides closure on a decades‐long diagnostic odyssey and underscores the importance of genetic sequencing in patients who present with unusual dermatologic findings.Keywords
Funding Information
- Michael Smith Foundation for Health Research
- Genome British Columbia (SIP007)
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